Expert Witness in Nanoparticle and Colloid Science
Specializing in Dynamic Light Scattering (DLS) and Zeta Potential (ELS)
Have a case involving particle size or zeta potential? Let’s talk.

About Dr. John F. Miller
With over 35 years of experience in colloid science and pharmaceutical development, Dr. John F. Miller combines deep technical expertise with courtroom-ready clarity in nanoparticle-related cases.
He founded Enlighten Scientific LLC in 2017 following a 24-year career at GlaxoSmithKline, where he served as the CMC lead for the ADVAIR® HFA inhaler, guiding its NDA submission and lifecycle management.
Dr. Miller holds a Ph.D. in colloid chemistry and is the inventor of Phase Analysis Light Scattering (PALS), a now-standard method for measuring zeta potential. His innovations extended particle analysis into challenging non-aqueous and viscous systems, and he developed custom analytical instruments and investigations to support product development and regulatory submissions.
His expertise spans nanoparticle formulation, inhaled drug delivery, and statistical data analysis, offering litigation teams precise, accessible insights grounded in scientific and industrial rigor.
Areas of Expertise
- Dynamic Light Scatterings (DLS)
- Electrophoretic Light Scattering (ELS)
- Colloidal Stability and Nanoparticle Behavior
- Expert Declarations and Deposition Support
- Product Liability and IP Cases
What You Can Expect
When you need a technical expert who can explain complex particle science clearly, I bring more than academic credentials. I’ve spent decades at the intersection of industry, research, and innovation, including inventing Phase Analysis Light Scattering (PALS), now widely used for measuring zeta potential.
I understand how to make complex data meaningful, not just to scientists, but to attorneys, juries, and regulatory bodies. I’m comfortable supporting litigation teams through consultation, technical writing, and deposition preparation.
Legal firms I have worked with
- Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Perkins Coie LLP
- Williams & Connolly LLP.
What I bring to the table
- Clear and jargon-free communication
- Experience with DLS/ELS in regulated settings
- Deep familiarity with product development timelines
- Honest, grounded, and detail-focused
- Available for short-turnaround reviews
Past cases
- Inhaled drug product patent challenges
- Nanoparticle formulation disputes
- Zeta potential measurement reliability
Protein Zeta Potential Analysis: Impact of Salt and pH
In my comprehensive study on the electrokinetic properties of bovine serum albumin (BSA) in potassium chloride solutions, I focused on the intricate effects of high salt concentrations and pH levels,
The Truth About Zeta Potential in High Conductivity Media
There’s a plethora of misconceptions about measuring zeta potential in high conductivity/high salt concentration media. Some even doubt the existence of zeta potentials under these conditions. Let’s set the record
Zeta Potential Measurement: Innovating in High Salt Concentration Environments
As an innovator in the field of zeta potential measurement, I am proud to introduce my latest development, a method specifically designed to excel in high salt concentration/high conductivity environments.
Whitepaper for Next Generation Electrophoretic Light Scattering
Welcome to a breakthrough in zeta potential measurement. I invite you to explore my in-depth whitepaper on Next Generation Electrophoretic Light Scattering (NG-ELS), a technology I proudly offer as a
See High Conductivity Zeta Potential Measurement in Action!
This video showcases the prototype of a Next Generation Electrophoretic Light Scattering instrument, proven to be capable of handling high conductivity samples with ionic strengths up to 6 molar, a
Zeta Potential Analysis in High Salt Conditions: Key Insights
Introduction: In the realm of colloidal science, accurately determining the zeta potential of particles in various environments is essential. However, when these environments feature high conductivity, standard measurement techniques face
Electrode Influence on Zeta Potential in High Salt Media
Key Role of Electrode Materials in Zeta Potential Measurement Zeta potential is a crucial parameter in understanding the stability of colloidal systems, and its accurate measurement is especially challenging in