This is the presentation given by Enlighten Scientific owner John F Miller at the American Chemical Society National Meeting in Boston on 23 August 2018. It is the first public talk about Enlighten Scientific’s ground-breaking Next Generation Electrophoretic Light Scattering system (NG-ELS) that surpasses any available commercial instrument for measuring ever-increasingly important high ionic strength samples with previously unobtainable accuracy and confidence. Key applications include intravenous and topical therapies, wastewater treatment, and desalination. Zeta potential distributions – not just phase analysis values – can be made up to 4M ionic strength. NG-ELS represents the first truly significant advance in zeta potential measurement via light scattering since John invented phase analysis light scattering (PALS) thirty years ago!